Universities have become more and more interconnected worldwide. As the global education scenario evolves, it is important for universities to understand the challenges and opportunities that surround them. The American Council on Education (ACE), a coordinating organization representing presidents of all types of accredited, degree-granting institutions in the U.S., convened the Blue Ribbon Panel on Global Engagement in 2010. The Panel analyzed the current environment and developed principles and practices that may serve as a framework for further global engagement by colleges and universities. A Blue Ribbon Panel report was produced and it discussed the challenges faced by universities in the 21st century; the American higher education in the global landscape; critical issues for American universities and the global engagement opportunities.